Cannondale
In production2005–

Synapse

road319916499 USD
01

Origin

Cannondale introduced the Synapse in 2006 as the brand's first dedicated endurance road bike — a category that barely existed at the time. The original Synapse pioneered "SAVE" (Synapse Active Vibration Elimination): micro-suspension flex zones engineered into the rear triangle and seatpost to dampen road buzz without the weight or maintenance of a real shock. A taller head tube and longer wheelbase gave it the all-day fit that endurance-bike buyers eventually came to expect. The Synapse was refreshed in 2014 with refined SAVE tubing and weight savings; the 2018 generation made disc brakes standard and opened tire clearance to 32 mm. The 2023 generation introduced integrated SmartSense lights and radar plus internal StashPort frame storage — a road bike with running lights and a glovebox. The latest LAB71 SmartSense model, the flagship of the line, hits €15,799 with a SRAM Red XPLR AXS 1x13 build and 32 mm tubeless tires. After almost twenty years and six generations, the Synapse is no longer a niche bike. It's how most road riders actually want to ride.

02

Specifications

Frame
Synapse Carbon / Hi-MOD Carbon, Proportional Response size-specific layup, BSA threaded BB, UDH, SmartSense-ready
Weight
kg
Drivetrain
Shimano 105 Di2 / Ultegra / SRAM Rival-Force AXS 2x12 by trim
Brakes
Hydraulic disc, flat mount, 12mm thru-axle
Wheels
Alloy/carbon endurance wheelset, tubeless-ready, 12x142mm rear / 12x100mm front
03

The verdict

+Strengths
  • BikeRadar: 42mm tyre clearance — 'go-anywhere potential' for road+light gravel
  • GranFondo LAB71: 'Far sportier than wide tire clearance and integrated lighting might initially suggest'
  • GranFondo: 'Compliant rear end does great job soaking up small bumps — hours without fatigue'
  • GranFondo: Stack:reach 1.52 (56cm) — 'noticeably more upright yet still efficient for fast all-day efforts'
  • Velo: StashPort 'one of nicest downtube storage hatches I've used on a road bike'
  • BSA 68mm threaded BB — no creak, easy service
  • UDH — SRAM T-Type and XPLR compatible, future-proof
  • Delta Steerer — internal or external routing choice
  • Proportional Response with size-specific compliance AND chainstay — genuine size optimization
  • SmartSense 2.0 on top models: integrated lights + Garmin Varia radar — safety + practicality
  • Reserve 42|49 asymmetric wheels on Carbon 1 — excellent value inclusion at €6,999
Weaknesses
  • GranFondo: LAB71 at €15,799 'one of most expensive all-road bikes on market'
  • Nminus1bikes: Claimed 42-48mm max clearance based on only 4mm gap — run 40mm with caution
  • Nminus1bikes: Chainstay grew 415→430mm — 'handling more toned-down than it used to be' vs gen 5
  • LAB71 SRAM Red XPLR 1x13 — gravel groupset on endurance road bike limits top-end sprinting
  • SmartSense adds ~400-500g — weight-conscious riders should avoid SmartSense variants
  • Nminus1bikes: Frame heavier than gen 5 (1,143g + 494g vs lighter gen 5) — StashPort adds weight
  • nminus1bikes: Mechanical shifting 'so-so at best' through convoluted internal housing paths
04

Who it’s for

Endurance road cyclists wanting all-day comfortAll-road riders (tarmac + light gravel)Sportive/gran fondo ridersYear-round road riders (fender mounts, wide clearance)Commuters wanting a performance road bike
05

Tags

06

Related models

Want one?

Find this bike on the marketplace, or compare notes with riders already on one.